Artifacts are one of the big progression systems in Sephiria 1.0, and if you’re used to picking up Relics during a run, don’t make the mistake of treating Artifacts the same way.
Unlike Relics, Artifacts are permanent unlocks. Once you’ve obtained one, it stays available on your account and can be equipped before future runs. More importantly, their effects can be strong enough to shape an entire build rather than simply giving you another small stat increase.
Artifacts become available in and beyond the Astral Vault in Chapter 7, with different types coming from bosses, Hard Mode, Infinite Mode, and secret rooms.
Sephiria 1.0 Artifacts Guide (August 2026) – How to Get Them
There are three main differences between Artifacts and Relics:
Artifacts are permanent. Relics are pickups you collect during individual runs, while an Artifact remains unlocked after you obtain it, similar to inscriptions.
Artifacts are equipped before a run. You can eventually equip up to two Artifacts through the account-wide Artifact menu.
Artifacts can define your build. Instead of giving you a basic stat bump, their passive effects can change how you approach combat, healing, exploration, or specific weapon mechanics.
Your first Artifact slot unlocks after defeating the Rabbit Goddess, while the second slot becomes available after clearing Hard Mode.
That second slot is where things become much more interesting because you can start pairing Artifacts whose effects complement each other.
How to Get Artifacts in Sephiria
Artifacts come from several endgame activities, so there isn’t one single place where you’ll find the entire collection.
| Source | Artifact Type | How It Works |
|---|---|---|
| Astral Guardian – Chapter 7 Mid-Boss | Combat Artifacts | Guaranteed drop on the first kill |
| Rabbit Goddess – Chapter 7 Final Boss | Boss Artifacts | Two drops per kill on Normal |
| Hard Mode Bosses | Cursed Artifacts | Exclusive Hard Mode Artifact pool |
| Infinite Mode Floors 25, 50 & 100 | Endless Artifacts | Floor 100 guarantees a Legendary Artifact |
| Star-Alignment Secret Rooms – Chapter 7 | Utility Artifacts | Requires completing constellation puzzles |
If you’re specifically trying to build up your Artifact collection, knowing which category you need first can save you from farming the wrong activity.
Combat Artifacts
Combat Artifacts are the straightforward offensive choices, but each one favors particular weapon styles.
| Artifact | Effect | Best With |
|---|---|---|
| Charged Core | Charge attacks deal +50% damage and charge 30% faster | Greatsword, Spear |
| Spellweaver’s Star | Spell-weave combos have a 15% chance to double-cast | Tome, Staff |
| Blood Moon Sigil | Lifesteal applies to all damage sources with +5% lifesteal | Fist, Scythe |
| Twin Fang | First attack against a new enemy deals 100% bonus damage | Bow, Fist |
Charged Core is naturally attractive if your playstyle already revolves around charge attacks. Instead of forcing a new mechanic into the build, it strengthens something Greatsword and Spear users are already doing.
Spellweaver’s Star fills a similar role for Tome and Staff builds, while Blood Moon Sigil is more interesting when you want your aggressive damage output to double as sustain.
Boss Artifacts
Boss Artifacts aren’t limited to pure damage. Some of their strongest benefits come from survivability, exploration, and expanding your run setup.
| Artifact | Effect | Best With |
|---|---|---|
| Goddess’s Halo | Every 30 seconds, your next hit heals for 25% of the damage dealt | Defensive setups / any weapon |
| Vault Key | Adds +1 Relic slot during runs, up to a maximum of nine Relics | Any build |
| Astral Compass | Reveals secret rooms and challenge chambers on the minimap | Exploration |
Goddess’s Halo is probably the easiest of these to fit into almost any setup. You don’t have to build around a particular weapon to benefit from periodic healing.
Vault Key, meanwhile, doesn’t directly increase your damage. Instead, the extra Relic slot gives you more room to develop your build as the run progresses.
Then there’s Astral Compass, which is the obvious exploration pick when your priority is finding hidden content rather than maximizing combat power.
Cursed Artifacts in Hard Mode
Cursed Artifacts are where the system gets risky. You receive a powerful benefit, but you’re also accepting a meaningful downside.
| Artifact | Benefit | Cost |
|---|---|---|
| Void Crown | +60% damage | Maximum HP reduced by 30% |
| Obsidian Heart | Dodge i-frames increased by 50% | Potions heal 50% less |
| Starve’s Token | Kills grant stacking +1% damage | Gold pickups are halved |
Void Crown is the classic high-risk damage option. The 60% damage increase is huge, but losing 30% of your maximum HP means mistakes become much more expensive.
Obsidian Heart takes a different approach. Longer dodge i-frames can make avoiding attacks easier, but your reduced potion healing means you can’t rely as heavily on recovery after taking damage.
Starve’s Token rewards you for continuing to kill enemies and building up its stacking damage bonus, with reduced gold income being the trade-off.
These aren’t Artifacts I’d equip without thinking about the downside first. The bonus might look great on paper, but the cost still has to fit the rest of your build.
Endless Artifacts in Infinite Mode
Infinite Mode has its own Artifact progression tied to specific floor milestones.
| Artifact | Effect | Unlock |
|---|---|---|
| Ascension Rune | +10% damage for every 10 floors climbed, resetting each run | Floor 25 |
| Floorwalker’s Boots | Enemies drop healing motes every 10 kills | Floor 50 |
| Eternity Shard | Revive once per run with 50% HP | Floor 100 |
The further you push into Infinite Mode, the better these rewards become.
Ascension Rune naturally gets stronger during longer climbs, while Floorwalker’s Boots provides extra sustain simply by continuing to kill enemies.
The big milestone is Floor 100, where you can unlock Eternity Shard. Getting a once-per-run revive at 50% HP gives you a valuable second chance during difficult runs.
Best Artifacts for Each Build
Once your second slot is available, pairing Artifacts becomes much more important.
| Build | Recommended Artifacts | Why It Works |
|---|---|---|
| Melee DPS – Greatsword/Fist | Charged Core + Twin Fang | Front-loads damage and strengthens an already aggressive playstyle |
| Mage – Tome/Staff | Spellweaver’s Star + Goddess’s Halo | Adds double-cast potential while giving fragile casters extra sustain |
| Hard Mode Survivability | Obsidian Heart + Vault Key | Longer dodge i-frames plus an additional Relic slot for defensive options |
| Co-op Support | Astral Compass + Floorwalker’s Boots | Helps the team find hidden rewards while providing additional healing opportunities |
These pairings aren’t something you absolutely have to follow, but they’re good starting points if you’ve unlocked several Artifacts and aren’t sure what to equip.
How to Farm Artifacts Faster
If your goal is simply to collect Artifacts, Astral Guardian is the most straightforward farming target. A practiced run can reach the encounter in around 20 minutes, and the guaranteed drop makes it a reliable option.
For Cursed Artifacts, you’ll need to move into Hard Mode. They share a drop pool, so using the Explorer’s Map Relic to maximize the number of chests you find during a run can help with farming.
There’s also no reason to worry about keeping duplicate Artifacts. Artifact unlocks are account-wide, and once you’ve collected one, that same Artifact won’t appear again as a duplicate.
Artifacts vs Relics – What’s the Difference?
This is probably the easiest part of the system to mix up when first getting into Sephiria’s endgame.
Think of it this way: Relics help build the run you’re currently playing, while Artifacts help define the build before that run even begins.
Artifacts stay unlocked permanently and can be equipped from your account-wide collection. Relics are still collected during individual runs.
That also means the two systems aren’t really competing with each other. They’re designed to work together.