Warframe Plague Star 2025 Guide – (Steel Path & Normal)

The Warframe Plague Star event returns in 2025 with minor tweaks but the same core gameplay. If you’re looking to farm Forma, standing, and resources, this guide will walk you through everything — including loadouts, speed strategies, drone routes, and build optimizations.

Warframe Plague Star 2025 Event Guide – (Steel Path & Normal)

1. Requirements to Participate

Before jumping in, make sure you have:

a. Infested Catalyst

• Fast travel to Dojo → Bio Lab
• Purchase the blueprint
• Craft 5 at a time

b. Eidolon Phylaxis

• Fast travel to Nakak in Cetus
• Select Operation: Plague Star offerings
• Purchase using standing (complete 1 basic bounty for enough standing)

Note: You can run either Normal or Steel Path versions.
The difference is in rewards:

2. Best Loadouts & Roles

a. Volt (Speed Support)

• Focus on speed boosts for the drone and player movement
• Use Roar as a subsume if Rest & Rage isn’t used
• Ideal Archwing: Itzal (speedy) or Elytron (if lacking Equinox)

Key Mod:

• Hyperion Thrusters (Archwing movement speed)
• Avoid crowd control on Heoite

b. Nova (Team Play / Drone Portals)

• Focus: Speed + Slow
• Use Speed at the boil, and Slow during defense phases
• Use Savior Decoy Augment to self-teleport after suicide setup

Build Tips:

• Add Bleeding Dragon Key and Decaying Dragon Key for low HP/shield setup
• Important mods: Sprint Boost, Overextended, Molt Augmented
• Keep energy pads on hand and spam as needed

c. Wisp (Support)

• Build for Strength to boost survivability
• Use Roar (Helminth) for DPS boosts
• Set up Motes before enemy swarms arrive

d. DPS Frames (Choose One)

• Mesa, Mirage, Mag, Saryn, or Sevagoth for clear
• Avoid destroying pods early — infested need to spawn consistently

3. How the Mission Works (Step-by-Step)

Phase 1: Mix Chemicals

• Use Infested Catalyst + Eidolon Phylaxis at start
• Insert chemicals into the truck
• Defend it — summon On-Call Crew for backup (3-minute duration is enough)

Phase 2: Drone Escort

• Bring the Mixer to the Africa spawn location
• Why Africa? This forces the Drone to spawn in an optimal path
• Nova can portal the drone to the boil
• Volt can press 2 to speed the drone

Map Marker Tip:
Place a lockpin at Africa spawn and make it visible on your HUD.

4. Quick Travel Trick (Speed Setup Method)

• Drop Necromech or K-Drive near the chemical pickup
• After grabbing the item, let enemies kill you
• You’ll respawn at the decoy point — use Nightwave dialogue skip to fast-forward
• This saves ~15-20 seconds per run

Reminder:
Use Decaying Dragon Key and Bleeding Dragon Key to drop your HP and shields — faster death = faster respawn.

5. Weapon Modding (Best Damage Types)

Heoite and Infested Weakness:

• Heat and Slash (Primary)
• Use weapons like Piranha Prime, Cedo, or Kuva Nukor

Weapon Setup Examples:

Piranha Prime

• Mods: Heat, Slash, Fire Rate, Reload Speed
• Arcane: Velocity (for fire rate)

Cedo

• Mods: Heat, Faction mod (Infested), Fire Rate, Shotgun Vendetta

Vastilok

• Used for Shattering Impact
• Add Dispatch Overdrive for movement speed on heavy attack

Do Not Use:

• Magus Lockdown, Freeze, or Petrify abilities that crowd control Heoite — it slows the run.

6. Nova Build (Team Setup)

• Helminth Slot: Decoy (with Savior Decoy augment)
• Key Mods: Sprint Boost, Molt Augmented, Overextended, Efficiency
• Health: Under 100 (use Dragon Keys)
• Shield: Under 100
• Purpose: Die quickly, teleport back, skip animation

Plague Star is the best event to farm Forma and test your group coordination. Use this guide to cut down your run times and maximize standing gain. Whether you’re playing casually or speedrunning with a premade squad, this setup will carry you through 2025’s Plague Star grind.